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Alexa Fluor(R) 488 anti-human/mouse/rat CD278 (ICOS)

Alexa Fluor(R) 488 anti-human/mouse/rat CD278 (ICOS)

Cat no: 313514

Supplier: BioLegend
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ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.
Catalogue number: 313514
Reactivities: Human, Mouse, Rat
Hosts: Hamster
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 100 microg
Clone: C398.4A
Gene: 100048841,29851,64545
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.5 microg per 106 cells in 100 microl volume. It is recommended that reagents be titrated for optimal performance in the particular application.* Alexa Fluor(R) 488 has a maximum emission of 519 nm when it is excited at 488 nm.** Alexa Fluor(R) is a registered trademark of Molecular Probes, Inc. Alexa Fluor(R) dye antibody conjugates are sold under license from Molecular Probes, Inc. for research use only, except for use in combination with microarrays and high content screening, and are covered by pending and issued patents.
Storage buffer: The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.
Concentration: 0.5 mg/ml
Antigen: Mouse T cell clone D10.G4.1
Isotype: Armenian Hamster IgG
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: Inducible COStimulatory molecule, H4
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