AKR1C3 Antibody

Aldo-keto reductase family 1 member C3 (AKR1C3) catalyzes the conversion of aldehydes and ketones to alcohols. AKR1C3 catalyzes the reduction of prostaglandin (PG) D2,PorcineGH2 and phenanthrenequinone (PQ) and the o, Xenopus/Amphibian,idation of 9-alpha,11-beta-PGF2 to PGD2. AKR1C3 functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. AKR1C3 can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. AKR1C3 preferentially transforms androstenedione (4-dione) to testosterone. AKR1C3 is strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. AKR1C3 is also inhibited by the flavinoid rutin, and by selective serotonin inhibitors (SSRIs).

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SPECIFICATIONS

Catalog Number

252019

Size

0.1 mg

Applications

IF

Reactivities

Hum

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human AKR1C3.

Isotype

Rabbit Ig

Accession

P42330

Additional Info

Aldo-keto reductase family 1 member C3; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; 3-alpha-hydro, Xenopus/Amphibian,ysteroid dehydrogenase type 2; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; Testosterone 17-beta-dehydrogenase 5; 17-beta-hydro, Xenopus/Amphibian,ysteroid dehydrogenase type 5; 17-beta-HSD 5; Prostaglandin F synthase; PGFS; Indanol dehydrogenase; Dihydrodiol dehydrogenase type I; Dihydrodiol dehydrogenase 3; DD-3; DD3; Chlordecone reductase homolog HAKRb; HA1753; AKR1C3; DDH1; HSD17B5; KIA0119; PGFS