Aldo-keto reductase family 1 member C3 (AKR1C3) catalyzes the conversion of aldehydes and ketones to alcohols. AKR1C3 catalyzes the reduction of prostaglandin (PG) D2,PorcineGH2 and phenanthrenequinone (PQ) and the o, Xenopus/Amphibian,idation of 9-alpha,11-beta-PGF2 to PGD2. AKR1C3 functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. AKR1C3 can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. AKR1C3 preferentially transforms androstenedione (4-dione) to testosterone. AKR1C3 is strongly inhibited by nonsteroidal anti-inflammatory drugs (NSAID) including flufenamic acid and indomethacin. AKR1C3 is also inhibited by the flavinoid rutin, and by selective serotonin inhibitors (SSRIs).