
Supplier:
Aviva Systems Biology IncorporatedAgtpbp1 (ATP/GTP binding protein 1 ) Blocking Peptide (the C terminal of Agtpbp1)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum, Mouse
Format
Lyophilized powder
Presku
AAP55206
Target
Agtpbp1 is a metallocarboxypeptidase that mediates deglutamylation of target proteins. It catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. It also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Agtpbp1 acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell differentiation, accumulation of tubulin polyglutamylation causing neurodegeneration.
Weight
128kDa
Gene Id
67269
Alternative Names
1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik; BB114605; CCP1; Nna1; mKIAA1035; nmf243; pcd
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