ADRA1B Antibody

Adrenergic Receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha 1 AR subtypes (1A/D, 1Bovine, and 1C), three alpha 2 ARs (2A, 2Bovine, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP 70),Porcineroto-oncogene e, Xenopus/Amphibian,pression, and mitogenesis have been linked to A1AR activation. The alpha-1B adrenergic receptor (ADRA1B) mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

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SPECIFICATIONS

Catalog Number

252032

Size

0.1 mg

Applications

IHC

Reactivities

Hum

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ADRA1B.

Isotype

Rabbit Ig

Accession

P35368

Additional Info

Alpha-1B adrenergic receptor; Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor; ADRA1B