Reactivities: | Human |
Presku: | AAP59961 |
Size: | 100ug |
Weight: | 57kDa |
Gene: | 147 |
Format: | Lyophilized powder |
Target: | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene |
Alternative names: | ADRA1; ALPHA1BAR |