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Adenovirus-9 E4 Orf1 Antibody (OAPB00730)

Adenovirus-9 E4 Orf1 Antibody (OAPB00730)

The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4). The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA

Hosts

Rabbit

Reactivities

Virus

Presku

OAPB00730

Target

Open reading frame 1 of the E4 region of Adenovirus 9

Alternative Names

Adenovirus-9 E4 Orf1; Ad-9 E4 Orf1

SUPPLIER INFO

Aviva Systems Biology Incorporated

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