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ADAM10 Antibody (OAPB00044)

ADAM10 Antibody (OAPB00044)

Proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-alpha, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-alpha, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB00044

Target

(CT) TNFalpha converting enzyme

Alternative Names

ADAM10 (CT); KUZ

SUPPLIER INFO

Aviva Systems Biology Incorporated

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