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ADAM-TS2 Antibody

ADAM-TS2 Antibody

Cat no: 251979

Supplier: ABBIOTEC
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A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) cleaves the propeptides of type I and II collagen prior to fibril assembly. ADAM-TS2 does not act on type III collagen. ADAM-TS2 also plays a role in development that is independent of its role in collagen biosynthesis. ADAM-TS2 cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln. It is e, Xenopus/Amphibian,pressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hypere, Xenopus/Amphibian,tensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperla, Xenopus/Amphibian,ity.
Catalogue number: 251979
Reactivities: Human
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: O95450
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human ADAM-TS2 protein.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5 % BSA with 0.09% sodium azide. Antibody was purified by immunogen-affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: A distintegrin and metalloproteinase with thrombospondin motifs 2; ADAMTS-2; ADAM-TS 2; ADAM-TS2; Procollagen I/II amino propeptide-processing enzyme; Procollagen I N-proteinase; PC I-NP; Procollagen N-endopeptidase; pNPI; ADAMTS2; PCINP; PCPNI
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