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Acetylcholinesterase (4E11) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250379

Acetylcholinesterase (4E11) Antibody

Acetylcholinesterase (AChE, EC.3.1.1.7.) is an enzyme located in the postsynaptic membrane and in the muscle endplates, where it hydrolyses the neurotransmitter acetylcholin. AChE from brain is a tetramer (G4-AChE) with a molecular mass of 320 kDa, AChE from erythrocytes is a dimer (G2-AChE) with a molecular mass of 170 kDa. Detection of higher levels of AChE in amniotic fluid can indicate fetal malformations such as neural tube defects. This antibody is specific for brain AChE and does not recognize AChE from erythrocytes. The antibody can thus distinguish between mammalian brain AChE and erythrocyte AChE. There is a weak cross-reactivity with Torpedo marmorata AChE but none with AChE from electric eel or human BtChE.

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SPECIFICATIONS

Catalog Number

250379

Size

0.2 mg

Applications

WB

Reactivities

Hum, Mouse, Bov

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

C-terminal 10 residues of brain acetylcholinesterase (human and bovine), absent from the erythrocyte enzyme.

Isotype

Mouse IgG1/k

Accession

P22303

Clonality

4E11

Additional Info

AChE

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