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Accn2 (amiloride-sensitive cation channel 2, neuronal ) Blocking Peptide (the N terminal of Accn2)(100ug)

Accn2 (amiloride-sensitive cation channel 2, neuronal ) Blocking Peptide (the N terminal of Accn2)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Accn2 Antibody (ARP35035_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP35035
Size: 100ug
Weight: 60kDa
Gene: The peptide is characterized by mass spectroscopy
Format: Lyophilized powder
Target: Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.
Alternative names: AI843610; ASIC; ASIC1; ASIC1a; B530003N02Rik; BNaC2
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