Supplier:
Aviva Systems Biology IncorporatedAccn2 (amiloride-sensitive cation channel 2, neuronal ) Blocking Peptide (the N terminal of Accn2)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Mouse
Format
Lyophilized powder
Presku
AAP35035
Target
Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.
Weight
60kDa
Gene Id
The peptide is characterized by mass spectroscopy
Alternative Names
AI843610; ASIC; ASIC1; ASIC1a; B530003N02Rik; BNaC2
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