Supplier:
Aviva Systems Biology Incorporated5-Methylcytosine (Methyl-CpG) Antibody (Clone #: 33D3)(50ug)
Prices direct from Aviva Systems Biology Incorporated
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SPECIFICATIONS
Size
50ug
Applications
ELISA, FC, IHC, WB
Hosts
Mouse
Reactivities
Hum, Mouse, Rat, Can, Ch/Bird, Prc, ZF/Fish
Clone
33D3
Format
1 mg/ml in 10mM phosphate buffer; 150 mM NaCl; pH 7.4
Presku
AMM99021
Target
Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.
Isotype
Mouse IgG1
Applications
ELISA, WB
Hosts
Mouse
Applications
IHC
Hosts
Mouse
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