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5-Methylcytosine (Methyl-CpG) Antibody (Clone #: 33D3)(50ug)

5-Methylcytosine (Methyl-CpG) Antibody (Clone #: 33D3)(50ug)

Supplier: Aviva Systems Biology Incorporated
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This is a mouse monoclonal antibody recognizes methylated CpG island. It was cited and validated on many applications, including: ELISA (0.1 microg/ml), Flow Cytometry (1 microg/ml), IHC of Cryo Sections (5-10 microg/ml), IHC of Paraffin Sections (5-10 microg/ml), and RIA (0.1 microg/ml).
Reactivities: Human, Mouse, Rat, Canine, Chicken/Bird, Porcine, Zebrafish/Fish
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Presku: AMM99021
Size: 50ug
Clone: 33D3
Format: 1 mg/ml in 10mM phosphate buffer; 150 mM NaCl; pH 7.4
Target: Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.
Isotype: Mouse IgG1
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