Reactivities: | Human, Mouse |
Presku: | AAP45841 |
Size: | 100ug |
Weight: | 12kDa |
Gene: | 20610 |
Format: | Lyophilized powder |
Target: | Sumo3 is a ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. It does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. It plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. |
Alternative names: | 2810014B19Rik; AA409334; AW121497; AW536077; D10Ertd345e; SMT3A; SUMO-3; Smt3h1 |