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Products Polyclonal Anti-SLC1A6
| Catalogue number: | PA2243 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100?g/vial |
| Gene: | SLC1A6 |
| Swiss prot: | P48664 |
| Form: | lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing. |
| Scientific background: | Excitatory amino acid transporter 4 (EAAT4), also known as Sodium-dependent glutamate/aspartate transporter is a protein that in humans is encoded by the SLC1A6 gene. This gene is mapped to 19p13.12. EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions. This gene seems to act as a symport by cotransporting sodium. |
| References: | 1. Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P., Amara, S. G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. ature 375: 599-603, 1995. 2. Jackson, M., Song, W., Liu, M.-Y., Jin, L., Dykes-Hoberg, M., Lin, C. G., Bowers, W. J., Federoff, H. J., Sternweis, P. C., Rothstein, J. D. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature 410: 89-93, 2001. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminus of human SLC1A6, identical to the related mouse and rat sequences. |
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