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Products Polyclonal Anti-mouse TNF alpha
| Catalogue number: | RP1000 |
| Price: | $240.00 |
| Reactivities: | Mouse |
| Applications: | Block/Neutralize/Inhibit, ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Conjugates: | Unconjugated, Agarose, Alkaline Phosphatase, Biotin, Gold, Horseradish Peroxidase, Blue emitters (<=499nm), Green emitters (500 to 529nm), Yellow emitters (530 to 559nm), Orange Emitters (560 to 589nm), Red emitters (590 to 629nm), Far-Red emitters (630 to 669nm), Near Infrared (NIR) (>=670nm), Other non-fluorescent conjugates |
| Size: | 100ug/vial |
| Gene: | TNF |
| Swiss prot: | P06804 |
| Form: | Lyophilized |
| Format: | Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | TNF(A)(Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| References: | 1. Shirai, T., Yamaguchi, H., Ito, H., Todd, C. W., Wallace, R. B.Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.Nature 313: 803-806, 1985. 2. Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., Goeddel, D. V.Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.Nature 312: 724-729, 1984. |
| Additional info: | E. coli-derived mouse TNF alpha recombinant protein (Position: L80-L235). |
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