Polyclonal Anti-DRD2

Price

200.00 USD

Size

100?g/vial

Reactivities

Hum, Mouse, Rat

Format

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.\n

References

1. Klein, T. A., Reuter, M., von Cramon, D. Y., Ullsperger, M. Response to comment on 'Genetically determined differences in learning from errors.' Science 321: 200-201, 2008.\n2. Schaefer, A., Im, H.-I., Veno, M. T., Fowler, C. D., Min, A., Intrator, A., Kjems, J., Kenny, P. J., O'Carroll, D., Greengard, P. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J. Exp. Med. 207: 1843-1851, 2010. \n3. Yujnovsky, I., Hirayama, J., Doi, M., Borrelli, E., Sassone-Corsi, P. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Nat. Acad. Sci. 103: 6386-6391, 2006.\n

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time.Avoid repeated freezing and thawing.

Scientific Background

Dopamine receptor D2, also known as D2R or D2DR is a protein that in humans is encoded by the DRD2 gene. DRD2 gene is mapped to 11q23.2. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.