Monoclonal Anti-Smad4 (DPC4)

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1089

Size

100ug/vial

Applications

ICC, WB

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(4089), Mouse(17128), Rat(50554 )

Swiss Prot

Human(Q13485), Mouse(P97471), Rat(O70437)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

JIP; DPC4; MADH4; MYHRS; MAD homolog 4; MAD,mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog 4 (Drosophila); SMA- AND MAD-RELATED PROTEIN 4; DELETED IN PANCREATIC CARCINOMA 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4

Primary Protein

Mothers against decapentaplegic homolog 4

Scientific Background

SMAD4 plays a pivotal role in signal transduction of the transforming growth factor beta superfamily cytokines by mediating transcriptional activation of target genes. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Mutational inactivation of SMAD4 causes TGF-beta unresponsiveness and gave a basis for understanding the physiologic role of this gene in tumorigenesis. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.