Monoclonal Anti-p53

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1078

Size

100ug/vial

Applications

ICC, IHC, IHC-Fr, WB

Reactivities

Hum

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(7157), Mouse(22059), Rat(24842)

Swiss Prot

Human(P04637), Mouse(P02340), Rat(P10361)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

LFS1; TRP53; Li-Fraumeni syndrome; TRANSFORMATION-RELATED PROTEIN 53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53

Primary Protein

Cellular tumor antigen p53

Scientific Background

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.