Monoclonal Anti-NF68

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1070

Size

100ug/vial

Applications

IHC, IHC-Fr, WB

Reactivities

Hum, Rat, Prc

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(4747), Mouse(18039 ), Rat(83613)

Swiss Prot

Human(P07196), Mouse(P08551), Rat(P19527)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

NFL; NF-L; NF68; CMT1F; CMT2E; 68 kDa neurofilament protein; Neurofilament triplet L protein\n

Primary Protein

Neurofilament light polypeptide\n

Scientific Background

Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 kD (NFL), 125 kD (NFM) and 200 kD (NFH) on SDS-gel electrophoresis. And they have a role in the maturation of regenerating myelinated axons. Neurofilament 68 (NF68), also called Neurofilament Protein, Light Chain (NFL). It is one of the most abundant cytoskeletal components of the neuron. Mutations in this gene were reported as a cause for autosomal dominant Charcot-Marie-Tooth type 2E (CMT2E) linked to chromosome 8p21. NFL was identified repeatedly in both screenings and found to interact with Myotubularin-related 2 gene, MTMR2 in both Schwann cells and neurons.