Monoclonal Anti-CDK4

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SPECIFICATIONS

Price

200.00 USD

Catalog Number

MA1020

Size

100ug/vial

Applications

ICC, WB

Reactivities

Hum, Mouse, Rat

Form

Lyophilized

Format

1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.

Gene Id

Human(1019), Mouse(12567), Rat(94201)

Swiss Prot

Human(P11802), Mouse(P30285), Rat(P35462)

Storage Temp

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Target Synonym

PSK-J3; CELL DIVISION KINASE 4; Cell division protein kinase 4

Primary Protein

Cyclin-dependent kinase 4

Scientific Background

Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. Human cell division is regulated primarily at the G1-to-S or the G2-to-M boundaries within the cell cycle. The complexes formed by CDK4 and the D-type cyclins are involved in the control of cell proliferation during the G1 phase. CDK4 is inhibited by p16, also known as cyclin-dependent kinase inhibitor-2. CDK4 is mapped to 12q14. CDK4 expression and activity are required for cytokine responsiveness in T cells.