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Products Monoclonal Anti- Catenin gamma (Plakoglobin)
| Catalogue number: | MA1012 |
| Price: | $200.00 |
| Reactivities: | Human, Bovine |
| Applications: | Immunocytochemistry, Immunohistochemistry - frozen, Western Blot |
| Size: | 100ug/vial |
| Gene: | Human(3728), Mouse(16480), Rat(81679) |
| Swiss prot: | Human(P14923), Mouse(Q02257), Rat(Q6P0K8) |
| Form: | Lyophilized |
| Format: | 1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml. |
| Target synonym: | DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12; Catenin gamma; Desmoplakin III; Desmoplakin-3 |
| Storage temp: | At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. |
| Primary protein: | Junction plakoglobin |
| Scientific background: | Junction Plakoglobin (JUP) ,also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. |
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