Purified anti-PLCgamma-1 Phosphorylated (Tyr783)

PLCgamma-1 is a ubiquitously expressed isozyme that is activated by phosphorylation of tyrosine 783. It plays important roles in mammalian growth and development, proliferation, differentiation, signal transduction, endocytosis, cytoskeletal reorganization, and activation of ion channels. In the brain, PLCgamma-1 is highly expressed and participates in brain development and synaptic transmission. Abnormal expression and activation of PLCgamma-1 is associated with various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Research in zebrafish also suggests its important roles in the maturation of granulocytes.