Purified anti-NKX2-1 (TTF-1)

NKX2-1 is a homeodomain containing transcription factor, responsible for regulating normal development and maintaining physiological functions of the lung, thyroid, and central nervous system. NKX2-1 appears to play a dual role in lung carcinogenesis. In lung tumors, NKX2-1 expression is significantly amplified. NKX2-1 is required for survival of lung adenocarcinoma and considered as a lineage survival oncogene. However, loss of NKX2-1 promotes metastasis in mouse lung adenocarcinoma. Lower NKX2-1 expression in human lung carcinoma have worse prognoses, suggesting that NKX2-1 inhibits tumor metastasis and acts as a tumor suppressor.

Prices direct from BioLegend

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

655402

Size

100 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

14D3A28

Antigen

Partial NKX2-1 recombinant protein (1-122 aa)

Gene Id

7080

Isotype

Mouse IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

NK-2, TEBP, NKX2A, TITF1, TTF-1, NKX2.1, TTF1 NKX2

Regulatory Status

RUO