Purified anti-GSK-3beta

GSK-3beta (glycogen synthase kinase-3 beta) is a 49 kD serine/threonine kinase that is a member of the CDC2/CDKX subfamily. This protein is expressed in the testis, thymus, prostate, and ovary, with weak expression in lung, brain, and kidney. GSK-3beta is thought to participate in the insulin and Wnt signaling pathway and has been shown to phosphorylate c-jun to reduce DNA binding. GSK-3beta can be modified by AKT phosphorylation which inhibits function. This protein has been shown to interact with axin and GBP/FRAT. The Poly6042 antibody recognizes human and mouse GSK-3beta and is cross-reactive with GSK-3alpha. The Poly6042 antibody has been shown to be useful for Western blotting.