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Purified anti-c-REL

Purified anti-c-REL

Cat no: 655802


Supplier: BioLegend
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c-Rel is a member of the Rel/NF-kappaB transcription factor family that forms homo or heterodimers with family members such as RelA/p65, RelB, NF-kappaB1/p105, and NF-kappaB2/p100. The NF-kappaB complex is retained in cytoplasm by the inhibitor IkappaB protein in unstimulated cells. Upon activation, IkappaB is degraded via the ubiquitin-proteasome pathway, which results in nuclear translocation of the active NF-kappaB complex. While other NF-kappaB transcription factors are expressed in most cell types, relatively higher levels of c-REL expression are found in hematopoietic cells. c-REL is thought to play key roles in regulating proliferation, differentiation, and survival of B and T lymphocytes.
Catalogue number: 655802
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100 microg
Clone: 2F5A22
Gene: 5966
Dilutions: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
Storage buffer: Upon receipt, store undiluted at 4C.
Concentration: 0.5 mg/ml
Antigen: Partial c-REL recombinant protein (453-587 a.a.)
Isotype: Mouse IgG2b, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: REL, V-Rel Avian Reticuloendotheliosis Viral Oncogene Homolog, Proto-Oncogene C-Rel