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Polyclonal Anti-SCG3

Polyclonal Anti-SCG3

Cat no: PA1071

Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Secretogranin-3 (SCG3) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.
Catalogue number: PA1071
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunocytochemistry, Immunohistochemistry, Immunohistochemistry - frozen, Western Blot
Size: 100ug/vial
Gene: SCG3
Swiss prot: Q8WXD2
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: SCG3 (secretogranin ?) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. SCG3 was the only gene within a haplotype block that contained rs3764220. SCG3 mRNA and immunoreactivity were detected in the paraventricular nucleus, lateral hypothalamic area, and arcuate nucleus, and the protein coexisted with orexin, melanin-concentrating hormone, neuropeptide Y, and proopiomelanocortin. SCG3 formed a granule-like structure together with these neuropeptides.
References: 1. Related Articles, LinksTanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K.Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity.J Clin Endocrinol Metab. 2007 Mar;92(3):1145-54. Epub 2007 Jan 2.
Additional info: A synthetic peptide corresponding to a sequence at the C-terminal of human SCG3, different from the related mouse and rat sequences by one amino acid.
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