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Products Polyclonal Anti-rat GH
| Catalogue number: | RP1007 |
| Price: | $240.00 |
| Reactivities: | Rat |
| Applications: | Block/Neutralize/Inhibit, ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot |
| Size: | 100ug/vial |
| Gene: | GH1 |
| Swiss prot: | P01244 |
| Form: | Lyophilized |
| Format: | Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Growth Hormone (GH) is mapped to 17q22-q24. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. Rat GH shares 98% amino acid sequence homology with mouse. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites. |
| References: | 1. Niall, H. D.; Hogan, M. L.; Sauer, R.; Rosenblum, I. Y.; Greenwood, F. C. : Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc. Nat. Acad. Sci. 68: 866-869, 1971. 2. Sundstrom, M.; Lundqvist, T.; Rodin, J.; Giebel, L. B.; Milligan, D.; Norstedt, G. : Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 angstrom resolution. J. Biol. Chem. 271: 32197-32203, 1996. |
| Additional info: | E. coli-derived rat GH recombinant protein (Position: F27-F216). |
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