Home  >  Products  >  Polyclonal Anti-human GH

Polyclonal Anti-human GH

Cat no: RP1023


Supplier: Boster Immunoleader
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Rabbit IgG polyclonal antibody for Somatotropin (GH1) detection. Tested with WB, IHC-P, ELISA in Human.
Catalogue number: RP1023
Price: $240.00
Reactivities: Human
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: GH1
Swiss prot: P01241
Form: Lyophilized
Format: Each vial contains 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: Growth Hormone (GH) is mapped to 17q22-q24. Growth hormone (GH) is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.
References: 1. Niall, H. D.; Hogan, M. L.; Sauer, R.; Rosenblum, I. Y.; Greenwood, F. C. : Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc. Nat. Acad. Sci. 68: 866-869, 1971. 2. Sundstrom, M.; Lundqvist, T.; Rodin, J.; Giebel, L. B.; Milligan, D.; Norstedt, G. : Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 angstrom resolution. J. Biol. Chem. 271: 32197-32203, 1996.
Additional info: E. coli-derived human GH recombinant protein (Position: F27-F217).