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Polyclonal Anti-Glut1

Cat no: PA1120


Supplier: Boster Immunoleader
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Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Catalogue number: PA1120
Price: $200.00
Reactivities: Human, Mouse, Rat
Applications: Immunohistochemistry, Western Blot
Size: 100ug/vial
Gene: SLC2A1
Swiss prot: P11166
Form: Lyophilized
Format: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage temp: "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. "
Scientific background: GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain1, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins2. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy3, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning4.
References: 1. Agus, D. B.; Gambhir, S. S.; Pardridge, W. M.; Spielholz, C.; Baselga, J.; Vera, J. C.; Golde, D. W. : Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J. Clin. Invest. 100: 2842-2848, 1997. 2. Manel, N.; Kim, F. J.; Kinet, S.; Taylor, N.; Sitbon, M.; Battini, J.-L. : The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115: 449-459, 2003. 3. Heilig, C. W.; Saunders, T.; Brosius, F. C., III; Moley, K.; Heilig, K.; Baggs, R.; Guo, L.; Conner, D. : Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc. Nat. Acad. Sci. 100: 15613-15618, 2003. 4. Lazar, V.; Bidart, J.-M.; Caillou, B.; Mahe, C.; Lacroix, L.; Filetti, S.; Schlumberger, M. : Expression of the Na(+)/I(-) symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J. Clin. Endocr. Metab. 84: 3228-3234, 1999.
Additional info: A synthetic peptide corresponding to a sequence at the N-terminal of human Glut1), different from the related mouse sequence by two amino acids, from the related rat sequence by one amino acid.