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Products Polyclonal Anti-CCR7
| Catalogue number: | PA1017 |
| Price: | $200.00 |
| Reactivities: | Human, Mouse, Rat |
| Applications: | Western Blot |
| Size: | 100ug/vial |
| Gene: | CCR7 |
| Swiss prot: | P32248 |
| Form: | Lyophilized |
| Format: | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Storage temp: | "At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing. " |
| Scientific background: | Schweickart et al.identified CCR7(also known as EBI1) in 1994, which is a lymphoid-specific member of the G protein-coupled receptor family. This gene, which is encoded on human chromosome 17q12-q21.2, is expressed in normal lymphoid tissues and in several B- and T-lymphocyte cell lines with 86% identity to the mouse homolog. It is also related to the receptors that recognize chemoattractants, such as interleukin-8, RANTES, C5a, and fMet-Leu-Phe. Expression of CCR7 controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets. |
| References: | 1. Schweickart VL, Raport CJ, Godiska R, Byers MG, Eddy RL Jr, Shows TB, Gray PW. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. Genomics.1994 Oct; 23(3):643-50. 2. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A.Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999 Oct 14; 401(6754):708-12. |
| Additional info: | A synthetic peptide corresponding to a sequence at the C-terminal of rat CCR7(347-363aa LSQERLRQWSSCRHVRH), different from the related mouse sequence by one amino acid, and from human sequence by two amino acids |
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