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Huma BACE1 (Partial length)(50ug)

Huma BACE1 (Partial length)(50ug)


Supplier: Aviva Systems Biology Incorporated
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Recombinant protein containging extra-cellular domain (from 28aa to 393aa) of human BACE1 protein was expressed in E. coli and further purified and refolded. It comes with native enzyme activity and is suitable for in vitro assay.
Presku: AEP00003
Weight: 55kDa
Gene: 23621
Target: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by BACE-1. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms of BACE-1 have been described.
Alternative names: ASP2; BACE; APP beta-secretase; asp 2; aspartyl protease 2; beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site APP cleaving enzyme 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving