Butyrl Cholinesterase catalyzes the hydrolysis of a number of choline esters according to the following reaction:
Acylcholine + H2O �� choline + acid
Horse Cholinesterase Butyryl��� is a tetrameric glycoprotein with four subunits of equal size, each having a molecular weight of 110 kDa. Butyryl cholinesterase hydrolyzes butyrylcholine four times more rapidly than acetylcholine. Unlike acetyl cholinesterase, it does not hydrolyze D-��-methyl acetylcholine. It is inhibited by 10-5 M physostigmine, numerous organophosphate esters, the carbamate derivates and quaternary ammonium salts.
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