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HCN1, S70-28

HCN1, S70-28

Cat no: SMC-304D


Supplier: StressMarq Biosciences Inc.
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Detects ~100kDa. No cross-reactivity against HCN2
Catalogue number: SMC-304D
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Clone: S70-28
Accession: NP_445827.1
Gene: 84390
Swiss prot: Q9JKBO
Dilutions: 1-10ug/mL (WB), 0.1-1.0ug/mL (Perox) (IHC/ICC), 1.0-10ug/mL (IF)
Form: Protein G Purified
Storage buffer: PBS pH7.4, 50% glycerol
Concentration: 1mg/mL
Isotype: IgG1
Shipping temp: Blue Ice or 4
Storage temp: -20
Research area: Channels and Transporters
Certificate of analysis: 1 ug/mL of SMC-304 was sufficient for detection of HCN1 in 10ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Scientific background: Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, play a crucial role in the regulatons of cell excitability. Importantly, they contribute to spontaneous rhythmic activity in both the heart and brain (3).
Alternative names: BCNG1, HAC2, potassium/sodium hyperpolarization activted cycli nucleotide gated channel 1
References: 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA. 2. www.iochannels.org 3. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232.