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C1s (9) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250213

C1s (9) Antibody

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 comple, Xenopus/Amphibian, (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2. This antibody is specific for C1s proenzyme and activated free C1s.

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SPECIFICATIONS

Catalog Number

250213

Size

0.2 mg

Reactivities

Hum

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

C1s proenzyme purified from human plasma

Isotype

Mouse IgG1/k

Accession

P09871

Clonality

9

Additional Info

C1 Esterase

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