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BUY 4-Aminopyridine

BUY 4-Aminopyridine

Cat no: A-115


Supplier: Alomone Labs Limited.
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4-Aminopyridine. A Non Specific K+ Channel Blocker.

Voltage-gated K+ channels (Kv ) play an important role in number of different aspects of the electrical responses of the nervous system. Their activity determines the frequency of action potential and the shape of the action potential waveform.
Furthermore, Kv channels may regulate the excitability of individual neurons, and may control the strength of synaptic contacts between neurons.
4-Aminopyridine (4-AP) is a non-selective Kv channel blocker, which can block a wide variety of Kv channels with different state dependences. Therefore, in search for clues for the structural determinants of Kv channels that are important for the state dependences of drug-channel interactions, 4-AP serves as a useful tool. For example, it blocks Kv 2.1 and Kv 3.1 channels with IC50 of 18 and 0.1 mM, respectively, in oocytes. Kv 1.1 and Kv 1.2 channels are blocked by 4-AP with IC50 of 147 μM and 230 μM, respectively, in CHO cells.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, characterized by axonal conduction block. 4-AP has been tested as a symptomatic treatment in patients with MS based on the clinical rationale that neurologic function could be improved by overcoming conduction block in demyelinated axons present in MS lesions. Indeed, 4-AP restored conduction in experimentally demyelinated nerves in the peripheral nervous system. In addition, 4-AP increased presynaptic action potential duration and amplitude leading to enhanced transmitter release.

Ion Channel Modulators; K+ Channel Blockers.
Catalogue number: A-115
Size: 100 g
Concentration: IC50 ~ 0.1-18 mM
Molecular weight: 94.1 da
Purity: >99%
Shipping temp: Room Temperature