anti-Dnmt3b antibody, affinity-purified (rabbit polyclonal)

Dnmt3b (DNA (cytosine-5-)-methyltransferase 3b) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics).?Dnmt3b is thought?to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene?cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Immunogen: Highly purified recombinant mouse Dnmt3b (amino acids 1-181) Applications 1) Western blotting (1,000-fold dilution) 2) Immunoprecipitation (1,000-fold dilution), useful for ChiP assays 3) Indirect immuno-fluorescence staining (1,000-fold dilution) 4) Immunohistochemistry (1000-fold)