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anti-DNA polymerase Eta (human) antibody, mouse monoclonal

Cat no: 70-071


Supplier: B-BRIDGE INTERNATIONAL, INC
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DNA polymerase eta ( 713 aa, 78 kDa) is specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at basic sites, but does not have lyase activity. Targets POLI (Pol iota) to replication foci.Xeroderma pigmentosum variant type (XPV) [MIM:278750]: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. XPV shows normal nucleotide excision repair, but an exaggerated delay in recovery of replicative DNA synthesis. Most patients with the variant type of xeroderma pigmentosum do not develop clinical symptoms and skin neoplasias until a later age. Clinical manifestations are limited to photo-induced deterioration of the skin and eyes.
Catalogue number: 70-071
Applications: Western Blot
Size: 100ug
Target: Human
Species: Mouse
Clonality: Monoclonal
Shipping temp: 4C
Storage temp: - 20 degree C

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