Polyclonal antibody against S. cerevisiae Cdc48. The Cdc48 protein in S. cerevisiae is involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. It acts as a chaperone that collects ubiquitinated substrates and has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Cdc48 is required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. It plays a role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD. Cdc48 consists of 836 amino acids with molecular mass of 92 kDa.
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