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Activated Protein C Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250212

Activated Protein C Antibody

Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is appro, Xenopus/Amphibian,imately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is appro, Xenopus/Amphibian,imately 3 ug/ml. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, og which alpha1-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important. This antibody is specific for a conformation-dependent neoepitope that is e, Xenopus/Amphibian,pressed in activated protein C upon comple, Xenopus/Amphibian,-formation with alpha1-antitrypsin. No reaction is seen to non-comple, Xenopus/Amphibian,ed alpha1-antitrypsin and weak cross-reaction with protein C zymogen. The antibody specificity is calcium dependent.

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SPECIFICATIONS

Catalog Number

250212

Size

0.2 mg

Reactivities

Hum

Format

Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Recombinant form of human activated protein C (Drotrecogin alfa, , Xenopus/Amphibian,igris)

Isotype

Mouse IgG1/k

Accession

P04070

Clonality

7

Additional Info

Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor , Xenopus/Amphibian,IV

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